Although flight emergencies are seen as a specific issue, they have gained importance due to the fact that airline transportation has become the most important domestic and international transportation tool actively used in almost every country today. Flight emergencies have become more important due to the gradual increase in passenger capacity and flight distances of aircraft in recent years. In general, there is no obligation to have a medical staff such as a doctor or nurse on duty to provide emergency medical assistance in case of the possibility of encountering emergency medical situations on commercial flights. However, first aid training is required for every aircraft personnel. With the increase in the number of flights around the world, the number of emergency medical conditions and deaths seen during flight has started to increase. 1 death is reported for every 1.5-4.7 billion passenger miles. In this review, information about emergency medical conditions encountered during flight, their management, emergency medical supplies and medicines to be found on board and the measures taken and to be taken on aircraft during the Covid-19 process are presented.